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Additionally, it has anti-inflammatory effect by reducing TNF- in lung tissue 15

Many studies highlight potential benefits in improving insulin sensitivity, glucose metabolism, and lipid profiles, but inconsistencies in dosing, study duration, and methodology limit definitive conclusions

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205,206 In addition, resident KCs attract circulating monocytes to sites of injury via CCL2 and indirectly stimulate endothelial cells to upregulate adhesion molecules like intercellular adhesion molecule 1 (ICAM-1), thereby enhancing monocyte recruitment

SAG uses a thioester (S-acyl) bond, which is cleaved specifically by cytoplasmic thioesterases, offering a more targeted intracellular release mechanism with a cleaner safety profile demonstrated in human dosing studies